Local anaesthetics: chloroprocaine: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Local anaesthetics: chloroprocaine

Sample item

Chloroprocaine is attractive for short spinal anaesthesia because of which property?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Very rapid hydrolysis by plasma cholinesterase and a short duration

Chloroprocaine is an ester with a plasma half-life of under a minute and gives a brief spinal block of about 40 to 60 minutes. It is also used for emergency epidural top-up.

Option by option

  • A. Very rapid hydrolysis by plasma cholinesterase and a short duration (correct)

    Correct. Rapid hydrolysis shortens its effect.

  • B. High cardiotoxicity

    It has low systemic toxicity.

  • C. Complete lack of metabolism

    It is metabolised rapidly.

  • D. Prolonged analgesia for 12 hours

    Its duration is short, not 12 hours.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is A, Very rapid hydrolysis by plasma cholinesterase and a short duration. Chloroprocaine is an ester with a plasma half-life of under a minute and gives a brief spinal block of about 40 to 60 minutes.

Why is "High cardiotoxicity" not the answer?

It has low systemic toxicity.

Why is "Complete lack of metabolism" not the answer?

It is metabolised rapidly.

Why is "Prolonged analgesia for 12 hours" not the answer?

Its duration is short, not 12 hours.

What concept does this question test?

It tests Local anaesthetics: chloroprocaine in Anaesthesia. It is also used for emergency epidural top-up.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Local anaesthetics: chloroprocaine?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.