Oral anatomy: Sjogren syndrome: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral anatomy: Sjogren syndrome

Sample item

A 45-year-old woman has dry mouth and dry eyes. Lip biopsy shows focal lymphocytic sialadenitis. Which antibodies support the diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Anti-Ro (SSA) and anti-La (SSB)

Sjogren syndrome shows lymphocytic infiltration of salivary and lacrimal glands, producing xerostomia and keratoconjunctivitis sicca. Anti-Ro and anti-La are typical antibodies, with rheumatoid factor often positive.

Option by option

  • A. Anti-Jo-1

    Anti-Jo-1 is linked to inflammatory myositis.

  • B. Anti-dsDNA

    Anti-dsDNA is specific for lupus.

  • C. Anti-centromere

    Anti-centromere is linked to limited scleroderma.

  • D. Anti-Ro (SSA) and anti-La (SSB) (correct)

    Correct. These antibodies characterise Sjogren syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is D, Anti-Ro (SSA) and anti-La (SSB). Sjogren syndrome shows lymphocytic infiltration of salivary and lacrimal glands, producing xerostomia and keratoconjunctivitis sicca.

Why is "Anti-Jo-1" not the answer?

Anti-Jo-1 is linked to inflammatory myositis.

Why is "Anti-dsDNA" not the answer?

Anti-dsDNA is specific for lupus.

Why is "Anti-centromere" not the answer?

Anti-centromere is linked to limited scleroderma.

What concept does this question test?

It tests Oral anatomy: Sjogren syndrome in Dentistry. Anti-Ro and anti-La are typical antibodies, with rheumatoid factor often positive.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral anatomy: Sjogren syndrome?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.