Oral pathology: McCune-Albright syndrome: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral pathology: McCune-Albright syndrome

Sample item

A girl has precocious puberty, cafe-au-lait macules and facial asymmetry with a ground-glass jaw lesion. Which gene is mutated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. GNAS

McCune-Albright syndrome is polyostotic fibrous dysplasia with endocrine hyperfunction and pigmentation, caused by post-zygotic activating GNAS mutation. The jaw shows a ground-glass radiographic pattern.

Option by option

  • A. GNAS (correct)

    Correct. GNAS mosaicism causes this syndrome.

  • B. SH3BP2

    SH3BP2 mutation causes cherubism.

  • C. RET

    RET mutation causes MEN 2.

  • D. PTCH1

    PTCH1 mutation causes Gorlin syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is A, GNAS. McCune-Albright syndrome is polyostotic fibrous dysplasia with endocrine hyperfunction and pigmentation, caused by post-zygotic activating GNAS mutation.

Why is "SH3BP2" not the answer?

SH3BP2 mutation causes cherubism.

Why is "RET" not the answer?

RET mutation causes MEN 2.

Why is "PTCH1" not the answer?

PTCH1 mutation causes Gorlin syndrome.

What concept does this question test?

It tests Oral pathology: McCune-Albright syndrome in Dentistry. The jaw shows a ground-glass radiographic pattern.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral pathology: McCune-Albright syndrome?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.