Transplantation: HLA matching: practice question

A General Surgery question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Surgery · Transplantation: HLA matching

Sample item

For renal transplantation, which HLA locus match has the greatest effect on graft survival?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. HLA-DR

Matching at the HLA-DR locus has the greatest influence, followed by HLA-B and then HLA-A. ABO compatibility and the crossmatch are also essential. Better matches reduce rejection and the need for heavy immunosuppression.

Option by option

  • A. HLA-DR (correct)

    Correct. HLA-DR matching matters most.

  • B. HLA-C

    HLA-C has less influence.

  • C. HLA-E

    HLA-E is not used in matching.

  • D. HLA-A

    HLA-A is less important than DR and B.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More General Surgery questions

Questions about this General Surgery question

What is the answer to this General Surgery question?

The best answer is A, HLA-DR. Matching at the HLA-DR locus has the greatest influence, followed by HLA-B and then HLA-A.

Why is "HLA-C" not the answer?

HLA-C has less influence.

Why is "HLA-E" not the answer?

HLA-E is not used in matching.

Why is "HLA-A" not the answer?

HLA-A is less important than DR and B.

What concept does this question test?

It tests Transplantation: HLA matching in General Surgery. ABO compatibility and the crossmatch are also essential. Better matches reduce rejection and the need for heavy immunosuppression.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Transplantation: HLA matching?

Learn classic signs and eponyms alongside what they diagnose. Then use the flashcards and the other General Surgery questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.