Muscle relaxants: aminoglycoside interaction: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Muscle relaxants: aminoglycoside interaction

Sample item

Which class of antibiotic potentiates non-depolarising neuromuscular block by reducing presynaptic acetylcholine release?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Aminoglycosides

Aminoglycosides such as gentamicin reduce presynaptic acetylcholine release and can prolong block, especially with magnesium or calcium channel blockers. Penicillins and cephalosporins do not significantly affect neuromuscular transmission.

Option by option

  • A. Fluoroquinolones

    Fluoroquinolones are not usually implicated in prolonged block.

  • B. Penicillins

    Penicillins do not potentiate neuromuscular blockers.

  • C. Cephalosporins

    Cephalosporins have no clinically important effect on the junction.

  • D. Aminoglycosides (correct)

    Correct. Aminoglycosides prolong block through reduced acetylcholine release.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is D, Aminoglycosides. Aminoglycosides such as gentamicin reduce presynaptic acetylcholine release and can prolong block, especially with magnesium or calcium channel blockers.

Why is "Fluoroquinolones" not the answer?

Fluoroquinolones are not usually implicated in prolonged block.

Why is "Penicillins" not the answer?

Penicillins do not potentiate neuromuscular blockers.

Why is "Cephalosporins" not the answer?

Cephalosporins have no clinically important effect on the junction.

What concept does this question test?

It tests Muscle relaxants: aminoglycoside interaction in Anaesthesia. Penicillins and cephalosporins do not significantly affect neuromuscular transmission.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Muscle relaxants: aminoglycoside interaction?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.