General anatomy and histology: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · General anatomy and histology

Sample item

A child has multiple fractures from minimal trauma, blue sclerae and poor dentition. A defect in synthesis of which collagen type underlies the disorder?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Type I

Osteogenesis imperfecta results from mutations in the genes for type I collagen, the main collagen of bone, tendon, skin and sclera. Type II is in hyaline cartilage, type III in reticular fibres and type IV in basement membranes.

Option by option

  • A. Type IV

    Type IV collagen forms basement membranes; its defect causes Alport syndrome.

  • B. Type I (correct)

    Correct. Type I collagen is the major structural protein of bone and sclera.

  • C. Type III

    Type III collagen forms reticular fibres; its defect causes vascular Ehlers-Danlos syndrome.

  • D. Type II

    Type II collagen forms hyaline cartilage and vitreous; its defects cause chondrodysplasias.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Anatomy questions

Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is B, Type I. Osteogenesis imperfecta results from mutations in the genes for type I collagen, the main collagen of bone, tendon, skin and sclera.

Why is "Type IV" not the answer?

Type IV collagen forms basement membranes; its defect causes Alport syndrome.

Why is "Type III" not the answer?

Type III collagen forms reticular fibres; its defect causes vascular Ehlers-Danlos syndrome.

Why is "Type II" not the answer?

Type II collagen forms hyaline cartilage and vitreous; its defects cause chondrodysplasias.

What concept does this question test?

It tests General anatomy and histology in Anatomy. Type II is in hyaline cartilage, type III in reticular fibres and type IV in basement membranes.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study General anatomy and histology?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.