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PSM · Environmental health: occupational bladder cancer
Sample itemA worker with 20 years of exposure in a dye factory presents with painless haematuria, and cystoscopy shows a papillary tumour. Which occupational agent is most likely responsible?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Aromatic amines such as beta-naphthylamine
Aromatic amines such as beta-naphthylamine and benzidine used in dye, rubber and chemical industries cause occupational bladder cancer after a long latent period. Vinyl chloride causes hepatic angiosarcoma. Asbestos causes mesothelioma and lung cancer.
Option by option
A. Inorganic arsenic
Arsenic is linked to skin, lung and bladder cancer from contaminated water, but the dye exposure here points to amines.
B. Vinyl chloride
Vinyl chloride exposure is linked to hepatic angiosarcoma.
C. Aromatic amines such as beta-naphthylamine (correct)
Correct. Aromatic amines in the dye industry cause bladder carcinoma.
D. Asbestos
Asbestos causes mesothelioma, asbestosis and bronchogenic carcinoma.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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