Reproduction: ovulation trigger: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Reproduction: ovulation trigger

Sample item

In the late follicular phase, rising oestradiol above a sustained threshold produces a large pituitary release of LH. What is this type of control?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Positive feedback of oestrogen on the pituitary and hypothalamus

Sustained high oestradiol from the dominant follicle switches from negative to positive feedback and produces the LH surge, which triggers ovulation about 10 to 12 hours later.

Option by option

  • A. Feedforward control by inhibin

    Inhibin selectively suppresses FSH.

  • B. Negative feedback of progesterone

    Progesterone acts mainly after ovulation to suppress gonadotropins.

  • C. Positive feedback of oestrogen on the pituitary and hypothalamus (correct)

    Correct. Oestrogen exerts positive feedback to give the LH surge.

  • D. Negative feedback of oestrogen

    Oestrogen is negative at low levels and early in the cycle.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is C, Positive feedback of oestrogen on the pituitary and hypothalamus. Sustained high oestradiol from the dominant follicle switches from negative to positive feedback and produces the LH surge, which triggers ovulation about 10 to 12 hours later.

Why is "Feedforward control by inhibin" not the answer?

Inhibin selectively suppresses FSH.

Why is "Negative feedback of progesterone" not the answer?

Progesterone acts mainly after ovulation to suppress gonadotropins.

Why is "Negative feedback of oestrogen" not the answer?

Oestrogen is negative at low levels and early in the cycle.

What concept does this question test?

It tests Reproduction: ovulation trigger in Physiology. The correct option holds because: Correct. Oestrogen exerts positive feedback to give the LH surge.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Reproduction: ovulation trigger?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.