Gynaecological oncology: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology

Sample item

A 16-year-old girl has a rapidly growing pelvic mass. Imaging shows a solid ovarian tumour and the serum AFP level is markedly raised. What is the most likely tumour?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Yolk sac (endodermal sinus) tumour

In an adolescent with an ovarian germ cell tumour, raised alpha-fetoprotein points to a yolk sac tumour, whose histological hallmark is the Schiller-Duval body. Dysgerminoma is associated with LDH, epithelial tumours with CA-125 and choriocarcinoma with hCG.

Option by option

  • A. Choriocarcinoma of the ovary

    Choriocarcinoma secretes hCG rather than AFP.

  • B. Yolk sac (endodermal sinus) tumour (correct)

    Correct. Yolk sac tumours secrete AFP and show Schiller-Duval bodies.

  • C. Dysgerminoma

    Dysgerminoma is a radiosensitive germ cell tumour with raised LDH and sometimes hCG.

  • D. Serous cystadenocarcinoma

    Serous cystadenocarcinoma occurs in older women and is followed by CA-125.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Yolk sac (endodermal sinus) tumour. In an adolescent with an ovarian germ cell tumour, raised alpha-fetoprotein points to a yolk sac tumour, whose histological hallmark is the Schiller-Duval body.

Why is "Choriocarcinoma of the ovary" not the answer?

Choriocarcinoma secretes hCG rather than AFP.

Why is "Dysgerminoma" not the answer?

Dysgerminoma is a radiosensitive germ cell tumour with raised LDH and sometimes hCG.

Why is "Serous cystadenocarcinoma" not the answer?

Serous cystadenocarcinoma occurs in older women and is followed by CA-125.

What concept does this question test?

It tests Gynaecological oncology in OBG. Dysgerminoma is associated with LDH, epithelial tumours with CA-125 and choriocarcinoma with hCG.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.