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OBG · Infertility
Sample itemA 29-year-old woman develops secondary amenorrhoea after vigorous curettage for retained products. She has normal FSH and no withdrawal bleed after oestrogen followed by progestogen. Which investigation is both diagnostic and potentially therapeutic?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Hysteroscopy
Amenorrhoea after uterine instrumentation with normal ovarian hormones and failed withdrawal bleeding indicates intrauterine adhesions (Asherman syndrome), meaning the outflow tract is the problem. Hysteroscopy shows the adhesions and allows adhesiolysis at the same sitting.
Option by option
A. Karyotyping
Karyotyping is for suspected chromosomal ovarian failure, which would show high FSH.
B. Pelvic ultrasound only
Ultrasound alone cannot reliably show thin adhesions and offers no treatment.
C. Hysteroscopy (correct)
Correct. Direct visualisation confirms adhesions and permits their division.
D. Serum prolactin
Prolactin assesses a hormonal cause, which does not fit the normal FSH and history.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.