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Anaesthesia · Regional anaesthesia
Sample itemTen minutes after a spinal block for caesarean section, a woman feels nauseated and her blood pressure falls markedly. What is the main mechanism of the hypotension?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Preganglionic sympathetic blockade causing vasodilatation and reduced venous return
Spinal anaesthesia blocks sympathetic outflow, producing arterial and venous dilatation and venous pooling. Aortocaval compression by the gravid uterus worsens this. Left uterine displacement, fluids and a vasopressor such as phenylephrine or ephedrine are used.
Option by option
A. Anaphylaxis to the local anaesthetic
Anaphylaxis is rare and would usually bring bronchospasm, rash or oedema.
B. Hypovolaemia from concealed haemorrhage
Nothing in the history suggests concealed bleeding, and the timing relates to the block.
C. Direct negative inotropic effect of the intrathecal drug on the myocardium
The small intrathecal dose has no significant direct myocardial depressant effect.
D. Preganglionic sympathetic blockade causing vasodilatation and reduced venous return (correct)
Correct. Sympathetic block with venous pooling is the usual cause.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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