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Anaesthesia · Regional anaesthesia
Sample itemA patient on prophylactic-dose low molecular weight heparin has been planned for spinal anaesthesia. What is the minimum recommended interval between the last prophylactic dose and the neuraxial puncture?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. 12 hours
Neuraxial anaesthesia in anticoagulated patients risks epidural or spinal haematoma and cord compression. After a prophylactic dose of LMWH, at least 12 hours should pass before needle placement, and about 24 hours after a therapeutic dose. The next dose is delayed for at least 4 hours after catheter removal.
Option by option
A. 48 hours
Forty-eight hours is longer than needed for a prophylactic dose.
B. 1 hour
One hour is too short to allow anti-Xa activity to fall.
C. 12 hours (correct)
Correct. A 12-hour gap after a prophylactic LMWH dose is the standard guidance.
D. 4 hours
Four hours applies to the delay before the next dose after catheter removal, not before puncture.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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