Paediatric infections: MIS-C: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Paediatric infections: MIS-C

Sample item

A 7-year-old with persistent fever for 5 days, rash, conjunctivitis, hypotension, raised CRP, ferritin and troponin, and a positive SARS-CoV-2 antibody test 4 weeks after a mild COVID-19 illness. What is the treatment?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. IVIG and corticosteroids with supportive care

MIS-C is a post-infectious hyperinflammatory syndrome with persistent fever, multi-organ involvement and raised inflammatory markers. IVIG and methylprednisolone, with supportive care and cardiac monitoring, are the mainstays.

Option by option

  • A. Oral antivirals alone

    Antivirals alone do not address the immune-mediated process.

  • B. Oral antibiotics alone

    Antibiotics alone do not treat the hyperinflammation.

  • C. IVIG and corticosteroids with supportive care (correct)

    Correct. IVIG plus steroids are first-line immunomodulators.

  • D. Antimalarials

    Antimalarials have no established role.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is C, IVIG and corticosteroids with supportive care. MIS-C is a post-infectious hyperinflammatory syndrome with persistent fever, multi-organ involvement and raised inflammatory markers.

Why is "Oral antivirals alone" not the answer?

Antivirals alone do not address the immune-mediated process.

Why is "Oral antibiotics alone" not the answer?

Antibiotics alone do not treat the hyperinflammation.

Why is "Antimalarials" not the answer?

Antimalarials have no established role.

What concept does this question test?

It tests Paediatric infections: MIS-C in Pediatrics. IVIG and methylprednisolone, with supportive care and cardiac monitoring, are the mainstays.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Paediatric infections: MIS-C?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.