Cardiovascular: mannitol contraindication: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Cardiovascular: mannitol contraindication

Sample item

In which situation is mannitol contraindicated?

AAcute glaucoma awaiting surgeryBActive intracranial haemorrhage with a bleeding source not controlledCRaised intracranial pressure from cerebral oedemaDOliguria with preserved renal function

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Active intracranial haemorrhage with a bleeding source not controlled

Mannitol is avoided in active intracranial bleeding because osmotic shrinkage can enlarge the haematoma, and it is also avoided in severe heart failure and pulmonary oedema because of volume expansion. It remains a standard agent for cerebral oedema and acute glaucoma.

Option by option

A. Acute glaucoma awaiting surgery
Acute glaucoma is an indication.
B. Active intracranial haemorrhage with a bleeding source not controlled (correct)
Correct. It can worsen bleeding when the vessel is not controlled.
C. Raised intracranial pressure from cerebral oedema
Raised intracranial pressure is an indication.
D. Oliguria with preserved renal function
Preserved renal function is not a contraindication.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Active intracranial haemorrhage with a bleeding source not controlled. Mannitol is avoided in active intracranial bleeding because osmotic shrinkage can enlarge the haematoma, and it is also avoided in severe heart failure and pulmonary oedema because of volume expansion.

Why is "Acute glaucoma awaiting surgery" not the answer?

Acute glaucoma is an indication.

Why is "Raised intracranial pressure from cerebral oedema" not the answer?

Raised intracranial pressure is an indication.

Why is "Oliguria with preserved renal function" not the answer?

Preserved renal function is not a contraindication.

What concept does this question test?

It tests Cardiovascular: mannitol contraindication in Pharmacology. It remains a standard agent for cerebral oedema and acute glaucoma.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cardiovascular: mannitol contraindication?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.