Haematology: tranexamic acid: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Haematology: tranexamic acid

Sample item

A woman with heavy menstrual bleeding is prescribed a drug that competitively blocks lysine binding sites on plasminogen. Which drug is this?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Tranexamic acid

Tranexamic acid is a lysine analogue that prevents plasminogen binding to fibrin and so inhibits fibrinolysis, reducing menstrual blood loss and trauma bleeding. It should be avoided in active thromboembolism.

Option by option

  • A. Alteplase

    Alteplase is a fibrinolytic.

  • B. Tranexamic acid (correct)

    Correct. A lysine analogue antifibrinolytic.

  • C. Streptokinase

    Streptokinase is a fibrinolytic.

  • D. Aspirin

    Aspirin impairs platelets and would worsen bleeding.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Tranexamic acid. Tranexamic acid is a lysine analogue that prevents plasminogen binding to fibrin and so inhibits fibrinolysis, reducing menstrual blood loss and trauma bleeding.

Why is "Alteplase" not the answer?

Alteplase is a fibrinolytic.

Why is "Streptokinase" not the answer?

Streptokinase is a fibrinolytic.

Why is "Aspirin" not the answer?

Aspirin impairs platelets and would worsen bleeding.

What concept does this question test?

It tests Haematology: tranexamic acid in Pharmacology. It should be avoided in active thromboembolism.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematology: tranexamic acid?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.