Portal hypertension: terlipressin: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Portal hypertension: terlipressin

Sample item

A man with cirrhosis presents with rapidly rising creatinine, ascites and no response to volume expansion, consistent with hepatorenal syndrome. Which vasoconstrictor with albumin is used?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Terlipressin

Terlipressin, a vasopressin analogue, constricts the splanchnic bed and improves renal perfusion in hepatorenal syndrome, given with albumin. It also controls variceal bleeding, but ischaemic adverse events limit its use.

Option by option

  • A. Dopamine

    Dopamine has no proven benefit.

  • B. Furosemide

    Furosemide reduces volume and may worsen renal failure.

  • C. Nitroglycerin

    Nitroglycerin lowers pressure and would not help.

  • D. Terlipressin (correct)

    Correct. Terlipressin with albumin is a standard approach.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Terlipressin. Terlipressin, a vasopressin analogue, constricts the splanchnic bed and improves renal perfusion in hepatorenal syndrome, given with albumin.

Why is "Dopamine" not the answer?

Dopamine has no proven benefit.

Why is "Furosemide" not the answer?

Furosemide reduces volume and may worsen renal failure.

Why is "Nitroglycerin" not the answer?

Nitroglycerin lowers pressure and would not help.

What concept does this question test?

It tests Portal hypertension: terlipressin in Pharmacology. It also controls variceal bleeding, but ischaemic adverse events limit its use.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Portal hypertension: terlipressin?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.