Cardiovascular: pulmonary hypertension drugs: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Cardiovascular: pulmonary hypertension drugs

Sample item

Bosentan, used in pulmonary arterial hypertension, acts through which mechanism?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Endothelin receptor antagonism

Bosentan blocks endothelin ETA and ETB receptors, reducing pulmonary vasoconstriction, and it is hepatotoxic and teratogenic. Sildenafil inhibits PDE5 and epoprostenol is a prostacyclin.

Option by option

  • A. Soluble guanylate cyclase stimulation

    Riociguat stimulates soluble guanylate cyclase.

  • B. Endothelin receptor antagonism (correct)

    Correct. Bosentan is an endothelin antagonist.

  • C. Prostacyclin analogue action

    Prostacyclin analogues include epoprostenol and treprostinil.

  • D. Phosphodiesterase 5 inhibition

    PDE5 inhibition is the action of sildenafil.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Endothelin receptor antagonism. Bosentan blocks endothelin ETA and ETB receptors, reducing pulmonary vasoconstriction, and it is hepatotoxic and teratogenic.

Why is "Soluble guanylate cyclase stimulation" not the answer?

Riociguat stimulates soluble guanylate cyclase.

Why is "Prostacyclin analogue action" not the answer?

Prostacyclin analogues include epoprostenol and treprostinil.

Why is "Phosphodiesterase 5 inhibition" not the answer?

PDE5 inhibition is the action of sildenafil.

What concept does this question test?

It tests Cardiovascular: pulmonary hypertension drugs in Pharmacology. Sildenafil inhibits PDE5 and epoprostenol is a prostacyclin.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cardiovascular: pulmonary hypertension drugs?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.