Neuro drugs: riluzole: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Neuro drugs: riluzole

Sample item

Which drug that reduces glutamate release prolongs survival modestly in amyotrophic lateral sclerosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Riluzole

Riluzole inhibits presynaptic glutamate release and blocks sodium channels, and slightly prolongs survival in ALS. Liver enzymes should be monitored.

Option by option

  • A. Pramipexole

    Pramipexole is a dopamine agonist.

  • B. Baclofen

    Baclofen relieves spasticity.

  • C. Donepezil

    Donepezil is a cholinesterase inhibitor for Alzheimer disease.

  • D. Riluzole (correct)

    Correct. Riluzole is the glutamate-modulating agent used in ALS.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Riluzole. Riluzole inhibits presynaptic glutamate release and blocks sodium channels, and slightly prolongs survival in ALS.

Why is "Pramipexole" not the answer?

Pramipexole is a dopamine agonist.

Why is "Baclofen" not the answer?

Baclofen relieves spasticity.

Why is "Donepezil" not the answer?

Donepezil is a cholinesterase inhibitor for Alzheimer disease.

What concept does this question test?

It tests Neuro drugs: riluzole in Pharmacology. Liver enzymes should be monitored.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuro drugs: riluzole?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.