Antiretrovirals: entry and long-acting agents: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Antiretrovirals: entry and long-acting agents

Sample item

Which drug blocks the CCR5 coreceptor, and which is a long-acting injectable integrase inhibitor?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Maraviroc and cabotegravir

Maraviroc is a CCR5 antagonist needing a tropism assay, enfuvirtide inhibits gp41-mediated fusion, and cabotegravir is an integrase inhibitor available as a long-acting injection for treatment and prevention.

Option by option

  • A. Enfuvirtide and raltegravir

    Enfuvirtide is a fusion inhibitor, not CCR5 antagonist.

  • B. Maraviroc and cabotegravir (correct)

    Correct. Maraviroc blocks CCR5, and cabotegravir is long acting.

  • C. Zidovudine and abacavir

    Zidovudine and abacavir are NRTIs.

  • D. Efavirenz and rilpivirine

    Efavirenz and rilpivirine are NNRTIs.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Maraviroc and cabotegravir. Maraviroc is a CCR5 antagonist needing a tropism assay, enfuvirtide inhibits gp41-mediated fusion, and cabotegravir is an integrase inhibitor available as a long-acting injection for treatment and prevention.

Why is "Enfuvirtide and raltegravir" not the answer?

Enfuvirtide is a fusion inhibitor, not CCR5 antagonist.

Why is "Zidovudine and abacavir" not the answer?

Zidovudine and abacavir are NRTIs.

Why is "Efavirenz and rilpivirine" not the answer?

Efavirenz and rilpivirine are NNRTIs.

What concept does this question test?

It tests Antiretrovirals: entry and long-acting agents in Pharmacology. The correct option holds because: Correct. Maraviroc blocks CCR5, and cabotegravir is long acting.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antiretrovirals: entry and long-acting agents?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.