Obstetric drugs: carboprost: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Obstetric drugs: carboprost

Sample item

Which statement about carboprost, used for atonic postpartum haemorrhage, is correct?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. It is contraindicated in asthma because it can cause bronchospasm

Carboprost is 15-methyl PGF2 alpha, a potent uterotonic given intramuscularly, which can cause bronchospasm, vomiting and diarrhoea, so it is avoided in asthma. Methylergometrine is avoided in hypertension and pre-eclampsia.

Option by option

  • A. It is safe in asthma

    It is not safe in asthmatics.

  • B. It is a PGE1 analogue

    Misoprostol is the PGE1 analogue.

  • C. It is a synthetic oxytocin analogue

    It is a prostaglandin, not an oxytocin analogue.

  • D. It is contraindicated in asthma because it can cause bronchospasm (correct)

    Correct. Bronchospasm contraindicates it in asthma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, It is contraindicated in asthma because it can cause bronchospasm. Carboprost is 15-methyl PGF2 alpha, a potent uterotonic given intramuscularly, which can cause bronchospasm, vomiting and diarrhoea, so it is avoided in asthma.

Why is "It is safe in asthma" not the answer?

It is not safe in asthmatics.

Why is "It is a PGE1 analogue" not the answer?

Misoprostol is the PGE1 analogue.

Why is "It is a synthetic oxytocin analogue" not the answer?

It is a prostaglandin, not an oxytocin analogue.

What concept does this question test?

It tests Obstetric drugs: carboprost in Pharmacology. Methylergometrine is avoided in hypertension and pre-eclampsia.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Obstetric drugs: carboprost?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.