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Anatomy · Embryology: germ cell tumours
Sample itemA newborn girl has a large mass projecting from the sacrococcygeal region and a high serum alpha-fetoprotein. Which embryological origin explains this tumour?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Remnants of pluripotent cells of the primitive streak
Sacrococcygeal teratoma arises from pluripotent cells of the primitive streak that persist in the caudal region, and it can contain tissues from all three germ layers. It is the commonest tumour of the newborn and is more frequent in girls. Notochord remnants give chordoma, and neural tube defects give myelomeningocele.
Option by option
A. Neural crest cells of the sacral region
Neural crest cells give neuroblastoma and melanocytic tumours, not teratomas.
B. Failure of closure of the caudal neuropore
Caudal neuropore failure gives a spinal defect such as meningomyelocele, not a teratoma.
C. Persistent notochord remnants
Notochord remnants give chordomas, a different tumour.
D. Remnants of pluripotent cells of the primitive streak (correct)
Correct. Primitive streak remnants are pluripotent and give teratomas.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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