Embryology: germ cell tumours: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · Embryology: germ cell tumours

Sample item

A newborn girl has a large mass projecting from the sacrococcygeal region and a high serum alpha-fetoprotein. Which embryological origin explains this tumour?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Remnants of pluripotent cells of the primitive streak

Sacrococcygeal teratoma arises from pluripotent cells of the primitive streak that persist in the caudal region, and it can contain tissues from all three germ layers. It is the commonest tumour of the newborn and is more frequent in girls. Notochord remnants give chordoma, and neural tube defects give myelomeningocele.

Option by option

  • A. Neural crest cells of the sacral region

    Neural crest cells give neuroblastoma and melanocytic tumours, not teratomas.

  • B. Failure of closure of the caudal neuropore

    Caudal neuropore failure gives a spinal defect such as meningomyelocele, not a teratoma.

  • C. Persistent notochord remnants

    Notochord remnants give chordomas, a different tumour.

  • D. Remnants of pluripotent cells of the primitive streak (correct)

    Correct. Primitive streak remnants are pluripotent and give teratomas.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is D, Remnants of pluripotent cells of the primitive streak. Sacrococcygeal teratoma arises from pluripotent cells of the primitive streak that persist in the caudal region, and it can contain tissues from all three germ layers.

Why is "Neural crest cells of the sacral region" not the answer?

Neural crest cells give neuroblastoma and melanocytic tumours, not teratomas.

Why is "Failure of closure of the caudal neuropore" not the answer?

Caudal neuropore failure gives a spinal defect such as meningomyelocele, not a teratoma.

Why is "Persistent notochord remnants" not the answer?

Notochord remnants give chordomas, a different tumour.

What concept does this question test?

It tests Embryology: germ cell tumours in Anatomy. It is the commonest tumour of the newborn and is more frequent in girls. Notochord remnants give chordoma, and neural tube defects give myelomeningocele.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Embryology: germ cell tumours?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.