Larynx and airway: adjuvant therapy for papillomatosis: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Larynx and airway: adjuvant therapy for papillomatosis

Sample item

A child with aggressive recurrent respiratory papillomatosis needs repeated surgery more than 4 times per year and has lung involvement. Which adjuvant drug has been used to reduce recurrence?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Bevacizumab, an anti-VEGF antibody

Intralesional or systemic bevacizumab and cidofovir are adjuvants in aggressive recurrent respiratory papillomatosis, aimed at reducing the frequency of surgery. HPV vaccination reduces incidence. Tracheostomy should be avoided, as it may seed the lower airway.

Option by option

  • A. Amphotericin B

    Amphotericin treats fungal infection.

  • B. Methotrexate

    Methotrexate is not an accepted therapy.

  • C. Isoniazid

    Isoniazid treats tuberculosis.

  • D. Bevacizumab, an anti-VEGF antibody (correct)

    Correct. Anti-VEGF therapy has been used successfully.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is D, Bevacizumab, an anti-VEGF antibody. Intralesional or systemic bevacizumab and cidofovir are adjuvants in aggressive recurrent respiratory papillomatosis, aimed at reducing the frequency of surgery.

Why is "Amphotericin B" not the answer?

Amphotericin treats fungal infection.

Why is "Methotrexate" not the answer?

Methotrexate is not an accepted therapy.

Why is "Isoniazid" not the answer?

Isoniazid treats tuberculosis.

What concept does this question test?

It tests Larynx and airway: adjuvant therapy for papillomatosis in ENT. HPV vaccination reduces incidence. Tracheostomy should be avoided, as it may seed the lower airway.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Larynx and airway: adjuvant therapy for papillomatosis?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.