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ENT · Head and neck tumours: cherubism
Sample itemA 5-year-old has symmetric painless bilateral swelling of the angles of the mandible giving a full-cheek appearance, with upward-turned eyes, and a family history. Radiographs show multilocular cysts. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Cherubism
Cherubism is an autosomal dominant fibro-osseous disorder due to SH3BP2 mutation, giving bilateral multilocular lesions of the jaws, usually regressing after puberty. Giant cells fill the lesions. Observation is usual, with surgery for severe deformity.
Option by option
A. Burkitt lymphoma
Burkitt lymphoma grows rapidly and is not symmetric.
B. Cherubism (correct)
Correct. Symmetric jaw swelling in a child with a family history.
C. Mumps
Mumps is acute with fever and affects the parotids.
D. Ameloblastoma
Ameloblastoma is usually unilateral in adults.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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