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ENT · Nose and paranasal sinuses: osteoma of the frontal sinus
Sample itemA young man has an incidental dense, well-circumscribed bony mass in the frontal sinus on CT. Multiple osteomas and colonic polyps are present in his family. Which syndrome is suspected?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Gardner syndrome
Osteoma is the commonest benign tumour of the paranasal sinuses, in the frontal sinus most often. Multiple osteomas with familial adenomatous polyposis are Gardner syndrome, due to APC mutation. Surgery is for symptoms such as mucocele or obstruction of the frontal recess.
Option by option
A. Gardner syndrome (correct)
Correct. Osteomas with colonic polyps indicate Gardner syndrome.
B. Lynch syndrome
Lynch syndrome is non-polyposis colorectal cancer.
C. Cowden syndrome
Cowden syndrome features hamartomas.
D. Gorlin syndrome
Gorlin syndrome features keratocysts and basal cell carcinomas.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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