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ENT · Pharynx and tonsils: lymphoma of Waldeyer's ring
Sample itemA 60-year-old has unilateral tonsillar enlargement with a smooth surface and a mass in the neck. Biopsy shows large CD20-positive B cells. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Diffuse large B-cell lymphoma
The tonsil is the commonest extranodal site in Waldeyer's ring for non-Hodgkin lymphoma, and diffuse large B-cell lymphoma is the commonest type. It presents with unilateral smooth tonsillar enlargement. Treatment is R-CHOP chemotherapy, with or without radiotherapy.
Option by option
A. Burkitt lymphoma
Burkitt lymphoma is more common in children and endemic regions.
B. Diffuse large B-cell lymphoma (correct)
Correct. DLBCL is the commonest tonsillar lymphoma.
C. Squamous cell carcinoma
Squamous carcinoma is usually ulcerated.
D. Hodgkin lymphoma
Hodgkin lymphoma shows Reed-Sternberg cells and is nodal.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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