Infertility: blastocyst transfer: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Infertility: blastocyst transfer

Sample item

In an IVF cycle, which description of a blastocyst-stage embryo transfer is correct?

ATransfer of a zygote on day 1BTransfer of an embryo on day 5 or 6 after fertilisation, with inner cell mass and trophectodermCTransfer of a 2-cell embryo on day 1DTransfer of an unfertilised oocyte

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Transfer of an embryo on day 5 or 6 after fertilisation, with inner cell mass and trophectoderm

A blastocyst is a day 5 to 6 embryo with a fluid cavity, an inner cell mass that forms the fetus and a trophectoderm that forms the placenta. Culture to this stage allows selection of embryos with the best developmental potential and supports single embryo transfer. Cleavage-stage embryos are transferred on day 2 or 3.

Option by option

A. Transfer of a zygote on day 1
Day 1 refers to the zygote stage.
B. Transfer of an embryo on day 5 or 6 after fertilisation, with inner cell mass and trophectoderm (correct)
Correct. Blastocysts are day 5 to 6 embryos.
C. Transfer of a 2-cell embryo on day 1
A 2-cell embryo is an earlier cleavage stage.
D. Transfer of an unfertilised oocyte
Unfertilised oocytes cannot be transferred.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Transfer of an embryo on day 5 or 6 after fertilisation, with inner cell mass and trophectoderm. A blastocyst is a day 5 to 6 embryo with a fluid cavity, an inner cell mass that forms the fetus and a trophectoderm that forms the placenta.

Why is "Transfer of a zygote on day 1" not the answer?

Day 1 refers to the zygote stage.

Why is "Transfer of a 2-cell embryo on day 1" not the answer?

A 2-cell embryo is an earlier cleavage stage.

Why is "Transfer of an unfertilised oocyte" not the answer?

Unfertilised oocytes cannot be transferred.

What concept does this question test?

It tests Infertility: blastocyst transfer in OBG. Culture to this stage allows selection of embryos with the best developmental potential and supports single embryo transfer. Cleavage-stage embryos are transferred on day 2 or 3.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infertility: blastocyst transfer?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.