Cornea: granular dystrophy: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Cornea: granular dystrophy

Sample item

A corneal dystrophy shows discrete white crumb-like deposits in the central anterior stroma with clear intervening stroma. The deposits stain with Masson trichrome. The substance is:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Hyaline

Granular dystrophy (TGFBI gene) deposits are hyaline and stain red with Masson trichrome. Macular dystrophy has acid mucopolysaccharide deposits that stain with Alcian blue and colloidal iron, and lattice dystrophy has amyloid. Macular is the only stromal dystrophy that is autosomal recessive.

Option by option

  • A. Lipid

    Lipid occurs in Schnyder and lipid keratopathy.

  • B. Acid mucopolysaccharide

    Acid mucopolysaccharide is in macular dystrophy.

  • C. Amyloid

    Amyloid is in lattice dystrophy.

  • D. Hyaline (correct)

    Correct. Granular dystrophy is hyaline and stains with Masson trichrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is D, Hyaline. Granular dystrophy (TGFBI gene) deposits are hyaline and stain red with Masson trichrome.

Why is "Lipid" not the answer?

Lipid occurs in Schnyder and lipid keratopathy.

Why is "Acid mucopolysaccharide" not the answer?

Acid mucopolysaccharide is in macular dystrophy.

Why is "Amyloid" not the answer?

Amyloid is in lattice dystrophy.

What concept does this question test?

It tests Cornea: granular dystrophy in Ophthalmology. Macular dystrophy has acid mucopolysaccharide deposits that stain with Alcian blue and colloidal iron, and lattice dystrophy has amyloid. Macular is the only stromal dystrophy that is autosomal recessive.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cornea: granular dystrophy?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.