Genetic bone disorders: nail-patella syndrome: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Genetic bone disorders: nail-patella syndrome

Sample item

A young man has dysplastic fingernails, hypoplastic patellae with recurrent dislocation and bilateral posterior iliac horns on pelvic radiograph. Which organ should be screened?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Kidney

Nail-patella syndrome is an autosomal dominant disorder caused by LMX1B mutation, with nail dysplasia, hypoplastic or absent patellae, elbow abnormalities and iliac horns. Renal involvement with proteinuria and nephropathy can occur, and glaucoma is also associated. Annual urine screening is recommended.

Option by option

  • A. Thyroid

    The thyroid is not typically involved.

  • B. Pancreas

    The pancreas is not typically involved.

  • C. Spleen

    The spleen is not typically involved.

  • D. Kidney (correct)

    Correct. Renal involvement is the key associated problem.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is D, Kidney. Nail-patella syndrome is an autosomal dominant disorder caused by LMX1B mutation, with nail dysplasia, hypoplastic or absent patellae, elbow abnormalities and iliac horns.

Why is "Thyroid" not the answer?

The thyroid is not typically involved.

Why is "Pancreas" not the answer?

The pancreas is not typically involved.

Why is "Spleen" not the answer?

The spleen is not typically involved.

What concept does this question test?

It tests Genetic bone disorders: nail-patella syndrome in Orthopaedics. Renal involvement with proteinuria and nephropathy can occur, and glaucoma is also associated. Annual urine screening is recommended.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Genetic bone disorders: nail-patella syndrome?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.