Antidepressants: moclobemide: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antidepressants: moclobemide

Sample item

A depressed patient needs an MAOI but wants to avoid dietary restriction. Which drug is a reversible inhibitor of MAO-A with minimal tyramine interaction?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Moclobemide

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), so tyramine can displace it and the cheese reaction is rare. Phenelzine and tranylcypromine irreversibly inhibit both isoforms and require dietary restriction. Moclobemide still interacts with serotonergic drugs.

Option by option

  • A. Tranylcypromine

    Tranylcypromine is an irreversible non-selective MAOI.

  • B. Phenelzine

    Phenelzine is an irreversible non-selective MAOI.

  • C. Selegiline oral high dose

    High-dose oral selegiline loses selectivity and inhibits MAO-A.

  • D. Moclobemide (correct)

    Correct. Moclobemide is a RIMA with minimal tyramine effect.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is D, Moclobemide. Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), so tyramine can displace it and the cheese reaction is rare.

Why is "Tranylcypromine" not the answer?

Tranylcypromine is an irreversible non-selective MAOI.

Why is "Phenelzine" not the answer?

Phenelzine is an irreversible non-selective MAOI.

Why is "Selegiline oral high dose" not the answer?

High-dose oral selegiline loses selectivity and inhibits MAO-A.

What concept does this question test?

It tests Antidepressants: moclobemide in Psychiatry. Phenelzine and tranylcypromine irreversibly inhibit both isoforms and require dietary restriction. Moclobemide still interacts with serotonergic drugs.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidepressants: moclobemide?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.