Antidepressants: vortioxetine: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antidepressants: vortioxetine

Sample item

Which antidepressant acts as a serotonin transporter inhibitor and a modulator of several 5-HT receptors, and may improve cognitive symptoms in depression?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Vortioxetine

Vortioxetine is a multimodal antidepressant that inhibits the serotonin transporter, is an antagonist at 5-HT3, 5-HT7 and 5-HT1D, and an agonist at 5-HT1A. It shows benefit on cognitive symptoms of depression with low sexual dysfunction. Nausea is the commonest adverse effect.

Option by option

  • A. Tianeptine

    Tianeptine is a serotonin reuptake enhancer in older description.

  • B. Trazodone

    Trazodone is a 5-HT2A antagonist and weak reuptake inhibitor.

  • C. Reboxetine

    Reboxetine is a selective noradrenaline reuptake inhibitor.

  • D. Vortioxetine (correct)

    Correct. Vortioxetine is multimodal with cognitive benefit.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is D, Vortioxetine. Vortioxetine is a multimodal antidepressant that inhibits the serotonin transporter, is an antagonist at 5-HT3, 5-HT7 and 5-HT1D, and an agonist at 5-HT1A.

Why is "Tianeptine" not the answer?

Tianeptine is a serotonin reuptake enhancer in older description.

Why is "Trazodone" not the answer?

Trazodone is a 5-HT2A antagonist and weak reuptake inhibitor.

Why is "Reboxetine" not the answer?

Reboxetine is a selective noradrenaline reuptake inhibitor.

What concept does this question test?

It tests Antidepressants: vortioxetine in Psychiatry. It shows benefit on cognitive symptoms of depression with low sexual dysfunction. Nausea is the commonest adverse effect.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidepressants: vortioxetine?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.