Antipsychotics: olanzapine-fluoxetine combination: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: olanzapine-fluoxetine combination

Sample item

A fixed combination approved for bipolar I depression and treatment-resistant depression contains

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Olanzapine and fluoxetine

The olanzapine-fluoxetine combination is approved for depressive episodes of bipolar I disorder and for treatment-resistant major depression. Quetiapine and lurasidone are other approved options for bipolar depression. Metabolic monitoring is important.

Option by option

  • A. Olanzapine and fluoxetine (correct)

    Correct. Olanzapine with fluoxetine is the approved combination.

  • B. Lithium and sertraline

    Lithium with sertraline is not a fixed approved combination.

  • C. Quetiapine and bupropion

    Quetiapine with bupropion is not a fixed combination.

  • D. Haloperidol and amitriptyline

    Haloperidol with amitriptyline is not recommended.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, Olanzapine and fluoxetine. The olanzapine-fluoxetine combination is approved for depressive episodes of bipolar I disorder and for treatment-resistant major depression.

Why is "Lithium and sertraline" not the answer?

Lithium with sertraline is not a fixed approved combination.

Why is "Quetiapine and bupropion" not the answer?

Quetiapine with bupropion is not a fixed combination.

Why is "Haloperidol and amitriptyline" not the answer?

Haloperidol with amitriptyline is not recommended.

What concept does this question test?

It tests Antipsychotics: olanzapine-fluoxetine combination in Psychiatry. Quetiapine and lurasidone are other approved options for bipolar depression. Metabolic monitoring is important.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: olanzapine-fluoxetine combination?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.