Drug interactions: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Drug interactions

Sample item

What is enzyme inhibition likely to do to a substrate drug concentration?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Raise it by slower metabolism

Enzyme inhibition slows metabolism of susceptible drugs and can raise their concentration, increasing the risk of dose-related adverse effects.

Option by option

  • A. Stop renal filtration

    Renal filtration does not stop because of enzyme inhibition.

  • B. Eliminate protein binding

    Protein binding is not eliminated by metabolic inhibition.

  • C. Raise it by slower metabolism (correct)

    Correct: inhibition can raise drug level by slowing metabolism.

  • D. Lower it by faster metabolism

    Faster metabolism and lower level result from induction.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Raise it by slower metabolism. Enzyme inhibition slows metabolism of susceptible drugs and can raise their concentration, increasing the risk of dose-related adverse effects.

Why is "Stop renal filtration" not the answer?

Renal filtration does not stop because of enzyme inhibition.

Why is "Eliminate protein binding" not the answer?

Protein binding is not eliminated by metabolic inhibition.

Why is "Lower it by faster metabolism" not the answer?

Faster metabolism and lower level result from induction.

What concept does this question test?

It tests Drug interactions in Pharmacology. The correct option holds because: Correct: inhibition can raise drug level by slowing metabolism.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Drug interactions?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.