Drug interactions: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Drug interactions

Sample item

What is enzyme induction likely to do to a substrate drug concentration?

APrevent absorption completelyBGuarantee toxicityCLower it by faster metabolismDRaise it by slower metabolism

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Lower it by faster metabolism

Enzyme induction increases metabolic capacity, so substrates of that pathway may be cleared faster and fall to lower plasma concentrations.

Option by option

A. Prevent absorption completely
Induction does not usually prevent gastrointestinal absorption completely.
B. Guarantee toxicity
Toxicity is not guaranteed because concentration may decrease.
C. Lower it by faster metabolism (correct)
Correct: induction often lowers substrate concentration via faster metabolism.
D. Raise it by slower metabolism
Slower metabolism and raised concentration occur with inhibition.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Lower it by faster metabolism. Enzyme induction increases metabolic capacity, so substrates of that pathway may be cleared faster and fall to lower plasma concentrations.

Why is "Prevent absorption completely" not the answer?

Induction does not usually prevent gastrointestinal absorption completely.

Why is "Guarantee toxicity" not the answer?

Toxicity is not guaranteed because concentration may decrease.

Why is "Raise it by slower metabolism" not the answer?

Slower metabolism and raised concentration occur with inhibition.

What concept does this question test?

It tests Drug interactions in Pharmacology. The correct option holds because: Correct: induction often lowers substrate concentration via faster metabolism.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Drug interactions?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.