Lipid metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Lipid metabolism

Sample item

What enzyme is responsible for rate-limiting fatty-acid synthesis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Acetyl-CoA carboxylase

Acetyl-CoA carboxylase forms malonyl-CoA, the committed rate-limiting step in fatty-acid synthesis and an important metabolic control point.

Option by option

  • A. Hormone-sensitive lipase

    Hormone-sensitive lipase mobilizes stored triglycerides in adipocytes.

  • B. Acetyl-CoA carboxylase (correct)

    Correct: acetyl-CoA carboxylase produces malonyl-CoA for fatty-acid synthesis.

  • C. HMG-CoA lyase

    HMG-CoA lyase participates in ketone-body synthesis.

  • D. Lipoprotein lipase

    Lipoprotein lipase hydrolyzes triglycerides in circulating lipoproteins.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Acetyl-CoA carboxylase. Acetyl-CoA carboxylase forms malonyl-CoA, the committed rate-limiting step in fatty-acid synthesis and an important metabolic control point.

Why is "Hormone-sensitive lipase" not the answer?

Hormone-sensitive lipase mobilizes stored triglycerides in adipocytes.

Why is "HMG-CoA lyase" not the answer?

HMG-CoA lyase participates in ketone-body synthesis.

Why is "Lipoprotein lipase" not the answer?

Lipoprotein lipase hydrolyzes triglycerides in circulating lipoproteins.

What concept does this question test?

It tests Lipid metabolism in Biochemistry. The correct option holds because: Correct: acetyl-CoA carboxylase produces malonyl-CoA for fatty-acid synthesis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Lipid metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.