Pharmacokinetics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacokinetics

Sample item

What route completely avoids first-pass hepatic metabolism?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Intravenous route

Intravenous administration delivers drug directly into systemic circulation, giving complete bioavailability and avoiding gastrointestinal absorption and first-pass hepatic metabolism.

Option by option

  • A. Oral route

    Oral drug commonly undergoes first-pass metabolism.

  • B. Intravenous route (correct)

    Correct: intravenous drug enters systemic circulation directly.

  • C. Rectal route always

    Rectal absorption can partly bypass first pass but is variable.

  • D. Sublingual route only

    Sublingual route can avoid first pass but is not the universal answer to complete bioavailability.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Intravenous route. Intravenous administration delivers drug directly into systemic circulation, giving complete bioavailability and avoiding gastrointestinal absorption and first-pass hepatic metabolism.

Why is "Oral route" not the answer?

Oral drug commonly undergoes first-pass metabolism.

Why is "Rectal route always" not the answer?

Rectal absorption can partly bypass first pass but is variable.

Why is "Sublingual route only" not the answer?

Sublingual route can avoid first pass but is not the universal answer to complete bioavailability.

What concept does this question test?

It tests Pharmacokinetics in Pharmacology. The correct option holds because: Correct: intravenous drug enters systemic circulation directly.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacokinetics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.