Diuretics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Diuretics

Sample item

What effect is typical of loop diuretics on calcium?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Increase calcium excretion

Loop diuretics reduce the lumen-positive potential in the thick ascending limb, decreasing paracellular calcium reabsorption and increasing calcium excretion.

Option by option

  • A. Decrease calcium excretion

    Thiazides decrease urinary calcium excretion.

  • B. Increase bone formation directly

    They do not directly build bone.

  • C. Increase calcium excretion (correct)

    Correct: loops increase urinary calcium loss.

  • D. No renal calcium effect

    Loop diuretics have clinically relevant calcium effects.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Increase calcium excretion. Loop diuretics reduce the lumen-positive potential in the thick ascending limb, decreasing paracellular calcium reabsorption and increasing calcium excretion.

Why is "Decrease calcium excretion" not the answer?

Thiazides decrease urinary calcium excretion.

Why is "Increase bone formation directly" not the answer?

They do not directly build bone.

Why is "No renal calcium effect" not the answer?

Loop diuretics have clinically relevant calcium effects.

What concept does this question test?

It tests Diuretics in Pharmacology. The correct option holds because: Correct: loops increase urinary calcium loss.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Diuretics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.