Nucleotide metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Nucleotide metabolism

Sample item

Which drug lowers uric acid production by inhibiting xanthine oxidase?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Allopurinol

Allopurinol inhibits xanthine oxidase and reduces conversion of purine metabolites into uric acid, making it useful for long-term urate-lowering therapy in appropriate patients with gout.

Option by option

  • A. Warfarin

    Warfarin inhibits vitamin K recycling in coagulation-factor synthesis.

  • B. Allopurinol (correct)

    Correct: allopurinol reduces uric-acid formation through xanthine oxidase inhibition.

  • C. Methotrexate

    Methotrexate interferes with folate metabolism and is used in cancer and inflammatory disease.

  • D. Metformin

    Metformin primarily reduces hepatic glucose production.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Allopurinol. Allopurinol inhibits xanthine oxidase and reduces conversion of purine metabolites into uric acid, making it useful for long-term urate-lowering therapy in appropriate patients with gout.

Why is "Warfarin" not the answer?

Warfarin inhibits vitamin K recycling in coagulation-factor synthesis.

Why is "Methotrexate" not the answer?

Methotrexate interferes with folate metabolism and is used in cancer and inflammatory disease.

Why is "Metformin" not the answer?

Metformin primarily reduces hepatic glucose production.

What concept does this question test?

It tests Nucleotide metabolism in Biochemistry. The correct option holds because: Correct: allopurinol reduces uric-acid formation through xanthine oxidase inhibition.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nucleotide metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.