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Biochemistry · Acid-base chemistry
Sample itemWhat is the most important extracellular buffer system in human blood?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Bicarbonate-carbonic acid
The bicarbonate-carbonic acid system is the principal extracellular buffer because its components are regulated by the lungs through carbon dioxide elimination and by the kidneys through bicarbonate handling.
Option by option
A. Haemoglobin only
Haemoglobin buffers within red cells but is not the main extracellular system.
B. Ammonia only
Ammonia buffering is important in renal acid excretion, not as the main plasma buffer.
C. Bicarbonate-carbonic acid (correct)
Correct: bicarbonate-carbonic acid is the dominant extracellular buffer.
D. Phosphate only
Phosphate is more important intracellularly and in renal tubular fluid.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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