Acid-base chemistry: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Acid-base chemistry

Sample item

What is the most important extracellular buffer system in human blood?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Bicarbonate-carbonic acid

The bicarbonate-carbonic acid system is the principal extracellular buffer because its components are regulated by the lungs through carbon dioxide elimination and by the kidneys through bicarbonate handling.

Option by option

  • A. Haemoglobin only

    Haemoglobin buffers within red cells but is not the main extracellular system.

  • B. Ammonia only

    Ammonia buffering is important in renal acid excretion, not as the main plasma buffer.

  • C. Bicarbonate-carbonic acid (correct)

    Correct: bicarbonate-carbonic acid is the dominant extracellular buffer.

  • D. Phosphate only

    Phosphate is more important intracellularly and in renal tubular fluid.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is C, Bicarbonate-carbonic acid. The bicarbonate-carbonic acid system is the principal extracellular buffer because its components are regulated by the lungs through carbon dioxide elimination and by the kidneys through bicarbonate handling.

Why is "Haemoglobin only" not the answer?

Haemoglobin buffers within red cells but is not the main extracellular system.

Why is "Ammonia only" not the answer?

Ammonia buffering is important in renal acid excretion, not as the main plasma buffer.

Why is "Phosphate only" not the answer?

Phosphate is more important intracellularly and in renal tubular fluid.

What concept does this question test?

It tests Acid-base chemistry in Biochemistry. The correct option holds because: Correct: bicarbonate-carbonic acid is the dominant extracellular buffer.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Acid-base chemistry?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.