Vitamin metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Vitamin metabolism

Sample item

Deficiency of which vitamin impairs hydroxylation steps needed for stable collagen cross-linking?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Vitamin C

Vitamin C is required for hydroxylation of proline and lysine residues during collagen synthesis, so deficiency weakens connective tissue and can cause gingival bleeding, bruising, and poor wound healing.

Option by option

  • A. Vitamin A

    Vitamin A is important for vision and epithelial differentiation.

  • B. Vitamin B6

    Vitamin B6 is involved in amino-acid metabolism and haem synthesis.

  • C. Vitamin E

    Vitamin E functions mainly as a lipid-soluble antioxidant.

  • D. Vitamin C (correct)

    Correct: vitamin C supports collagen hydroxylation and connective-tissue strength.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is D, Vitamin C. Vitamin C is required for hydroxylation of proline and lysine residues during collagen synthesis, so deficiency weakens connective tissue and can cause gingival bleeding, bruising, and poor wound healing.

Why is "Vitamin A" not the answer?

Vitamin A is important for vision and epithelial differentiation.

Why is "Vitamin B6" not the answer?

Vitamin B6 is involved in amino-acid metabolism and haem synthesis.

Why is "Vitamin E" not the answer?

Vitamin E functions mainly as a lipid-soluble antioxidant.

What concept does this question test?

It tests Vitamin metabolism in Biochemistry. The correct option holds because: Correct: vitamin C supports collagen hydroxylation and connective-tissue strength.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vitamin metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.