Vitamin metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Vitamin metabolism

Sample item

Vitamin K is necessary for gamma-carboxylation of which group of coagulation factors?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. II, VII, IX, and X

Vitamin K enables gamma-carboxylation of factors II, VII, IX, and X, allowing them to bind calcium effectively on phospholipid surfaces during normal coagulation cascade activity.

Option by option

  • A. Only factor XIII

    Factor XIII stabilizes fibrin but is not the vitamin K-dependent set.

  • B. Only von Willebrand factor

    von Willebrand factor has a different role in platelet adhesion and factor VIII carriage.

  • C. II, VII, IX, and X (correct)

    Correct: factors II, VII, IX, and X are vitamin K dependent.

  • D. I, V, VIII, and XII

    Factors I, V, VIII, and XII are not the classic vitamin K-dependent group.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is C, II, VII, IX, and X. Vitamin K enables gamma-carboxylation of factors II, VII, IX, and X, allowing them to bind calcium effectively on phospholipid surfaces during normal coagulation cascade activity.

Why is "Only factor XIII" not the answer?

Factor XIII stabilizes fibrin but is not the vitamin K-dependent set.

Why is "Only von Willebrand factor" not the answer?

von Willebrand factor has a different role in platelet adhesion and factor VIII carriage.

Why is "I, V, VIII, and XII" not the answer?

Factors I, V, VIII, and XII are not the classic vitamin K-dependent group.

What concept does this question test?

It tests Vitamin metabolism in Biochemistry. The correct option holds because: Correct: factors II, VII, IX, and X are vitamin K dependent.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vitamin metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.