Anticoagulants: direct oral anticoagulants: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Anticoagulants: direct oral anticoagulants

Sample item

Which direct oral anticoagulant directly inhibits thrombin (factor IIa) rather than factor Xa?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Dabigatran

Dabigatran is a direct thrombin inhibitor. Apixaban, rivaroxaban and edoxaban inhibit factor Xa, reducing thrombin generation upstream.

Option by option

  • A. Rivaroxaban

    Rivaroxaban is a direct factor Xa inhibitor.

  • B. Dabigatran (correct)

    Correct. Dabigatran binds and inhibits factor IIa directly.

  • C. Edoxaban

    Edoxaban is a direct factor Xa inhibitor.

  • D. Apixaban

    Apixaban is a direct factor Xa inhibitor.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Dabigatran. Dabigatran is a direct thrombin inhibitor.

Why is "Rivaroxaban" not the answer?

Rivaroxaban is a direct factor Xa inhibitor.

Why is "Edoxaban" not the answer?

Edoxaban is a direct factor Xa inhibitor.

Why is "Apixaban" not the answer?

Apixaban is a direct factor Xa inhibitor.

What concept does this question test?

It tests Anticoagulants: direct oral anticoagulants in Pharmacology. Apixaban, rivaroxaban and edoxaban inhibit factor Xa, reducing thrombin generation upstream.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Anticoagulants: direct oral anticoagulants?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.