Antihypertensives: ACE inhibitors: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Antihypertensives: ACE inhibitors

Sample item

A patient develops a persistent dry cough after beginning enalapril. Accumulation of which mediator most directly explains it?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Bradykinin

ACE both forms angiotensin II and degrades bradykinin. ACE inhibition raises bradykinin, contributing to cough and, rarely, angioedema.

Option by option

  • A. Endothelin-1

    Endothelin is not the usual mechanism of ACE-inhibitor cough.

  • B. Bradykinin (correct)

    Correct. Bradykinin accumulation is responsible for the characteristic cough.

  • C. Angiotensin II

    Angiotensin II falls with ACE inhibition.

  • D. Aldosterone

    Aldosterone decreases downstream of reduced angiotensin II.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Bradykinin. ACE both forms angiotensin II and degrades bradykinin.

Why is "Endothelin-1" not the answer?

Endothelin is not the usual mechanism of ACE-inhibitor cough.

Why is "Angiotensin II" not the answer?

Angiotensin II falls with ACE inhibition.

Why is "Aldosterone" not the answer?

Aldosterone decreases downstream of reduced angiotensin II.

What concept does this question test?

It tests Antihypertensives: ACE inhibitors in Pharmacology. ACE inhibition raises bradykinin, contributing to cough and, rarely, angioedema.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antihypertensives: ACE inhibitors?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.