Antidiabetic drugs: GLP-1 receptor agonists: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Antidiabetic drugs: GLP-1 receptor agonists

Sample item

Which effect contributes to weight loss with semaglutide?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Delayed gastric emptying and increased satiety

GLP-1 receptor agonists enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and increase satiety. Nausea is common, especially during dose escalation.

Option by option

  • A. Blockade of intestinal fat absorption

    Orlistat blocks fat absorption, not semaglutide.

  • B. Direct destruction of pancreatic alpha cells

    GLP-1 therapy modulates hormones; it does not destroy alpha cells.

  • C. Delayed gastric emptying and increased satiety (correct)

    Correct. These gastrointestinal and central effects reduce energy intake.

  • D. Increased renal glucose reabsorption

    SGLT2 inhibitors reduce rather than increase renal glucose reabsorption.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Delayed gastric emptying and increased satiety. GLP-1 receptor agonists enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and increase satiety.

Why is "Blockade of intestinal fat absorption" not the answer?

Orlistat blocks fat absorption, not semaglutide.

Why is "Direct destruction of pancreatic alpha cells" not the answer?

GLP-1 therapy modulates hormones; it does not destroy alpha cells.

Why is "Increased renal glucose reabsorption" not the answer?

SGLT2 inhibitors reduce rather than increase renal glucose reabsorption.

What concept does this question test?

It tests Antidiabetic drugs: GLP-1 receptor agonists in Pharmacology. Nausea is common, especially during dose escalation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antidiabetic drugs: GLP-1 receptor agonists?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.