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Dermatology · Skin cancer
Sample itemWhich lesion feature is most concerning for squamous cell carcinoma?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Persistent hyperkeratotic ulcerated lesion on sun-exposed skin
Cutaneous squamous cell carcinoma may present as a persistent scaly hyperkeratotic or ulcerated lesion, especially on chronically sun-exposed skin.
Option by option
A. Persistent hyperkeratotic ulcerated lesion on sun-exposed skin (correct)
Correct: persistent keratotic ulceration needs malignancy assessment.
B. Stable symmetric mole since childhood
Longstanding symmetric moles are usually lower risk.
C. Transient urticarial wheal
Wheals resolve quickly and are not carcinoma.
D. Soft pedunculated skin tag
Skin tags are usually benign.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.