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Anaesthesia · Oxygen delivery
Sample itemWhich variable has the greatest effect on arterial oxygen content in most patients?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Haemoglobin concentration
Arterial oxygen content is approximately 1.34 times haemoglobin times saturation plus a small dissolved component. Therefore anaemia can markedly reduce oxygen content despite a normal pulse oximetry value.
Option by option
A. Serum bicarbonate
Bicarbonate influences acid-base state, not primary oxygen carriage.
B. Dissolved oxygen only
Dissolved oxygen is usually a small fraction at normal pressures.
C. Haemoglobin concentration (correct)
Correct. Most oxygen is carried bound to haemoglobin.
D. Respiratory rate alone
Respiratory rate affects ventilation but does not determine oxygen content by itself.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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