Pharmacokinetics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacokinetics

Sample item

What happens to drug half-life when clearance falls but volume of distribution is unchanged?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Half-life increases

Half-life is proportional to volume of distribution and inversely proportional to clearance, so reduced clearance prolongs elimination when distribution is unchanged.

Option by option

  • A. Half-life decreases

    Half-life would shorten only if clearance rose.

  • B. Protein binding disappears

    Protein binding is not abolished by clearance reduction.

  • C. Bioavailability becomes zero

    Bioavailability concerns absorption and first-pass handling.

  • D. Half-life increases (correct)

    Correct: slower clearance prolongs drug elimination.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Half-life increases. Half-life is proportional to volume of distribution and inversely proportional to clearance, so reduced clearance prolongs elimination when distribution is unchanged.

Why is "Half-life decreases" not the answer?

Half-life would shorten only if clearance rose.

Why is "Protein binding disappears" not the answer?

Protein binding is not abolished by clearance reduction.

Why is "Bioavailability becomes zero" not the answer?

Bioavailability concerns absorption and first-pass handling.

What concept does this question test?

It tests Pharmacokinetics in Pharmacology. The correct option holds because: Correct: slower clearance prolongs drug elimination.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacokinetics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.