Pharmacokinetics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacokinetics

Sample item

What is the main clinical consequence of a high volume of distribution?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Less drug remains confined to plasma

A high volume of distribution indicates extensive tissue distribution relative to plasma concentration and may reduce removal by haemodialysis.

Option by option

  • A. Less drug remains confined to plasma (correct)

    Correct: high Vd implies substantial tissue partitioning.

  • B. Oral absorption is complete

    Absorption is a separate pharmacokinetic process.

  • C. The drug cannot enter tissue

    High Vd means the drug does enter tissue.

  • D. Renal clearance must be zero

    Clearance can still be significant.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is A, Less drug remains confined to plasma. A high volume of distribution indicates extensive tissue distribution relative to plasma concentration and may reduce removal by haemodialysis.

Why is "Oral absorption is complete" not the answer?

Absorption is a separate pharmacokinetic process.

Why is "The drug cannot enter tissue" not the answer?

High Vd means the drug does enter tissue.

Why is "Renal clearance must be zero" not the answer?

Clearance can still be significant.

What concept does this question test?

It tests Pharmacokinetics in Pharmacology. The correct option holds because: Correct: high Vd implies substantial tissue partitioning.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacokinetics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.