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Pharmacology · Anticoagulants
Sample itemWhich laboratory test is used to monitor unfractionated heparin therapy?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Activated partial thromboplastin time
Unfractionated heparin activity is commonly monitored with activated partial thromboplastin time or anti-Xa measurement because of variable pharmacokinetics.
Option by option
A. International normalized ratio
INR is used for vitamin K antagonist monitoring.
B. Serum creatinine only
Creatinine informs dosing risk but not anticoagulant intensity.
C. Activated partial thromboplastin time (correct)
Correct: aPTT reflects the intrinsic-pathway anticoagulant effect.
D. Bleeding time
Bleeding time is not a heparin monitoring test.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.