Anticoagulants: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Anticoagulants

Sample item

What is the mechanism of direct oral factor Xa inhibitors?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Direct inhibition of factor Xa

Direct oral factor Xa inhibitors reduce thrombin generation by selectively inhibiting activated factor X without requiring antithrombin as an intermediary.

Option by option

  • A. Platelet cyclooxygenase inhibition

    Aspirin inhibits platelet cyclooxygenase.

  • B. Direct inhibition of factor Xa (correct)

    Correct: they block Xa-mediated thrombin generation.

  • C. Vitamin K recycling inhibition

    Warfarin inhibits vitamin K recycling.

  • D. Activation of antithrombin only

    Heparin acts through antithrombin.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Direct inhibition of factor Xa. Direct oral factor Xa inhibitors reduce thrombin generation by selectively inhibiting activated factor X without requiring antithrombin as an intermediary.

Why is "Platelet cyclooxygenase inhibition" not the answer?

Aspirin inhibits platelet cyclooxygenase.

Why is "Vitamin K recycling inhibition" not the answer?

Warfarin inhibits vitamin K recycling.

Why is "Activation of antithrombin only" not the answer?

Heparin acts through antithrombin.

What concept does this question test?

It tests Anticoagulants in Pharmacology. The correct option holds because: Correct: they block Xa-mediated thrombin generation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Anticoagulants?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.