Gynecologic oncology: endometrial cancer: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynecologic oncology: endometrial cancer

Sample item

Which factor increases risk of endometrial hyperplasia and carcinoma?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Chronic unopposed estrogen exposure

Unopposed estrogen promotes endometrial proliferation and increases the risk of hyperplasia and carcinoma. Obesity, anovulation, and estrogen-only therapy in a person with a uterus are relevant contexts.

Option by option

  • A. Combined estrogen-progestogen therapy

    Progestogen opposes estrogenic stimulation of the endometrium.

  • B. Copper intrauterine device use

    Copper IUD does not create unopposed estrogen exposure.

  • C. Chronic unopposed estrogen exposure (correct)

    Correct. Persistent estrogen without progestogen drives endometrial proliferation.

  • D. Long-term breastfeeding only

    Breastfeeding is not a classic risk factor for endometrial cancer.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Chronic unopposed estrogen exposure. Unopposed estrogen promotes endometrial proliferation and increases the risk of hyperplasia and carcinoma.

Why is "Combined estrogen-progestogen therapy" not the answer?

Progestogen opposes estrogenic stimulation of the endometrium.

Why is "Copper intrauterine device use" not the answer?

Copper IUD does not create unopposed estrogen exposure.

Why is "Long-term breastfeeding only" not the answer?

Breastfeeding is not a classic risk factor for endometrial cancer.

What concept does this question test?

It tests Gynecologic oncology: endometrial cancer in OBG. Obesity, anovulation, and estrogen-only therapy in a person with a uterus are relevant contexts.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynecologic oncology: endometrial cancer?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.